Gene Therapies May Offer Promising Mesothelioma Treatments Compared to Radiation Therapy

17 07 2009

Oncologists choose what type of treatment to go with for every patient. The options are endless. There are no standard treatment course for peritoneal mesothelioma cancer victims. This is due to the cancers high mortality rate, rareness, low treatment success rate, and small number of studies to provide meaningful statistics.

The prospects for mesothelioma patients have been grim, but doctors have recently made progress. Traditional treatments for cancer are surgery (removing the tumor and surrounding tissue), radiation (killing the cancerous cells with radiation), and chemotherapy (poisoning the cancerous cells.) There are problems with all three. Patients with mesothelioma have not responded well to traditional radiation therapy. Researchers are looking for ways of aiming radiation directly at the tumor in hopes that this will result in less damage to healthy tissue.

Surgery removes the mesothelial tissue around the tumor. The surgery is difficult and challenging, with unknown effects or benefits to patients. Common chemotherapy drugs that work on other types of cancer usually do not work on mesothelioma, and different mixtures of these drugs have not been successful. As with radiation, research is going toward controlling the physical location of the treatment with emphasis on the pleural cavity.

The high-mortality rate for mesothelioma patients means cutting-edge techniques for cancer are tried out. Such treatments include anti-angiogenesis drugs like thalidomide and biologic therapies agent interleukin 2. Pemetrexed (Alimta) is a new drug that has shown results in extending life.

Considered by oncologists is where the tumor is located, what stage the mesothelioma is in, and the age and health of the patient. Theres also photodynamic therapy and gene therapy ” two far-out new ways of attacking cancer. Mesothelioma patients sometimes become involved in clinical trials in this area, and see benefits.

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